Diabetes type II (formerly called non-insulin-dependent or adult-onset) results from the body’s ineffective use of insulin. Type II diabetes comprises 90% of people with diabetes around the world, and is largely the result of excess body weight and physical inactivity. Type II diabetes is the most common form of diabetes. In 2014, 9% of adults 18 years and older had diabetes. In 2012 diabetes was the direct cause of 1.5 million deaths.
What are common consequences of diabetes?
Over time, diabetes can damage the heart, blood vessels, eyes, kidneys, and nerves. It can increases the risk of heart disease and stroke (cardiovascular disease). Diabetes is also among the leading causes of kidney failure.
Combined with reduced blood flow, neuropathy (nerve damage) in the feet increases the chance of foot ulcers, infection and eventual need for limb amputation. Diabetic retinopathy is an important cause of blindness, and occurs as a result of long-term accumulated damage to the small blood vessels in the retina.
We are looking into the use of our SUL-compounds for diabetes targeted drug development. Preliminary studies with an animal model and our SUL-compounds gave promising results.