Great news! A new scientific paper has been published about the potential of a new medicine, SUL-138, to help treat sepsis. Sepsis is a serious health problem, but right now doctors can only use antibiotics and supportive care to help patients. SUL-138 targets the mitochondria, which are the “powerhouses” of cell and can cause organ problems in sepsis. The study, performed by Bastiaan Star, dr. Hjalmar Bouma and co-authors from the department of Clinical Pharmacy and Pharmacology at University Medical Center Groningen, found that SUL-138 improved outcomes in mice with sepsis, and the researchers are hopeful that it could be a promising new treatment option for patients.
SUL-138 improved mitochondrial function resulting in limitation of systemic inflammation and preservation of kidney function
In this study, scientists gave SUL-138 to mice before and after inducing sepsis, and it helped to keep their kidneys and mitochondria working properly. This means that levels of certain chemicals in the blood that indicate kidney problems didn’t increase as much as they would have without the treatment. SUL-138 also helped to reduce inflammation and bring the mice’s body temperature back up. The scientists believe that SUL-138 could be a good treatment to prevent organ damage in people with sepsis because it seems to be safe and effective.
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