The first publication of 2019 is a fact, D. Nakladal from the University Medical Center Groningen (UMCG) investigated the effects of SUL-121 and its enantiomers SUL-150 and SUL-151 on vasorelaxation in porcine intrarenal arteries. Enantiomers are molecules with a same chemical structure, however with a different chirality which is more commonly described as a mirror image or left and right hand of a molecule. Interestingly, enantiomers can therefore have different biological effects which is also demonstrated in this publication.
(R)-enantiomer of SUL-121 has extra protective effects towards donor kidneys
SUL-121 increases the perfusion of porcine kidneys through its (R)-enantiomer or right hand: SUL-150. This finding may have great implications for kidney transplantation, wherein the hypothermic storage of donor kidneys damages the kidney’s vasculature, which constricts and limits kidney perfusion after transplantation. Limited kidney perfusion is a known-cause of transplant organ failure. Current hypothermic storage solutions in kidney transplantation use a combination of vasodilators, antioxidants and anti-inflammatory agents to protect the kidney transplant. SUL-150 has all these properties and may therefore have a distinct advantage over conventional agents.